Synthesis of Novel 3’,3’‐cyclic Dinucleotide Analogues Targeting STING Protein

Novel Linezolid like Analogues: Synthesis, Characterization and Biological Evaluation

The synthesis of 4-(substituted benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one was achieved in two steps, In first step, pyrazine-2-carboxamide  dissolved in EtOH, 10% KOH solution with ClCH2COOH produced compound 2-(pyrazine-2-carboxamido) acetic acid (II) and in second step, compound (II) in (CH3CO)2O with aromatic aldehyde, and catalyst potassium ace...

synthesis of vitamin e novel analogues as anti-cancer compounds

background antioxidant compounds have been shown to slow down the development of chemically induced tumors. it has been estimated that most of human cancer cases are due to environmental factors and would be preventable if the main risks could be identified. the potential of vitamin e as a cancer preventive agent has been studied and individuals whose intake of vitamin e was above average showe...

design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues

Substituted Nicotinamide Analogues of Nicotinamide Adenine Dinucleotide*

A number of nicotinamide adenine dinucleotide analogues have been prepared in which the purine, pyridine, and ribose moieties have been modified (2-12). These analogues have proven to be valuable in studies dealing with the site of binding of the pyridine coenzyme to dehydrogenases, in elucidating the mechanism of dehydrogenases and the configuration of the pyridme coenzymes, and as indicators ...

Substituted Nicotinamide Analogues of Nicotinamide Adenine Dinucleotide.

A number of nicotinamide adenine dinucleotide analogues have been prepared in which the purine, pyridine, and ribose moieties have been modified (2-12). These analogues have proven to be valuable in studies dealing with the site of binding of the pyridine coenzyme to dehydrogenases, in elucidating the mechanism of dehydrogenases and the configuration of the pyridme coenzymes, and as indicators ...